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Feb 15, 2025 · This approach enhances the evidence base for clinical decision-making and guideline development. Therefore, we conducted a systematic review and network meta-analysis to compare the efficacy of various pharmacological interventions—including standard treatments and emerging therapies—on metabolic and hormonal outcomes in women with PCOS.
In this systematic review, meta-analysis, and meta-regression, we aimed to assess the highest quality evidence available on the impact of insulin sensitizers on key metabolic and reproductive outcomes in women with PCOS and overweight or obesity.
Jul 19, 2021 · For PCOS is a chronic progressive disorder, the management should address the long-term efficacy. Accordingly, we performed this network meta-analysis to compare the effectiveness of 55 pharmacological interventions across 17 different clinical and biochemical outcomes in overweight PCOS patients for both short- and long-term follow-ups.
Feb 22, 2024 · Introduction Polycystic ovary syndrome (PCOS) is a common condition in women, characterised by reproductive and metabolic dysfunction. While dietary approaches have been evaluated as a first-line treatment for patients with PCOS, there is limited evidence to support preference for a specific dietary composition. This systematic review and network meta …
May 20, 2025 · This systematic review and meta-analysis aimed to evaluate the effects of ketogenic diet (KD) and very-low-energy ketogenic therapy (VLEKT) protocols on various health outcomes in patients with polycystic ovary syndrome (PCOS) and increased body weight.
Jun 28, 2025 · Summary Weight loss interventions exert differential effects on PCOS-related symptoms. Future studies should focus on optimizing combination strategies to enhance treatment efficacy. Currently, evidence on the impact of these interventions on pregnancy rates and long-term reproductive outcomes in overweight or obese women with PCOS is limited.
Aug 21, 2024 · Background: Currently, the primary strategy for addressing polycystic ovarian syndrome (PCOS) involves lifestyle modifications, with a focus on weight loss. The purpose of this meta-analysis was to assess the impact of weight loss through dietary interventions on inflammatory status and hyperandrogenism in PCOS women. Methods: A comprehensive …
Jan 1, 2022 · The surge in GnRH in turn produces excessive Luteinising hormone (LH) and the sequential events hyperstimulate ovaries to produce more testosterone [16]. Another explanation theory of PCOS syndrome is based on endocrinological perturbation of insulin axis like hyperinsulinemia and insulin resistance.
Nov 1, 2021 · They observed the amelioration in weight, free testosterone, LH: FSH ratio, and fasting insulin [56]. Serum androgens were also reported to be lowered in individuals who had been consuming a high-fat diet, then began taking an isocaloric, high-fiber, low-fat …
The hormones, including insulin, GH, ghrelin, LEAP-2, GnRH, insulin, the LH/FSH ratio, androgens, and estrogens, are abnormally changed with close correlation in the diagnosis and clinical manifestations of PCOS, which provides novel directions for the treatment of PCOS.
Mar 1, 2025 · Reductions in total testosterone, free androgen index, anti-Müllerian hormone (AMH), and luteinizing hormone (LH) levels were observed, alongside increased sex hormone-binding globulin (SHBG). TRF also improved insulin sensitivity, reduced body weight, and decreased inflammatory markers, all of which contribute to enhanced reproductive outcomes.
Nov 1, 2023 · Polycystic ovary syndrome (PCOS) is one of the most prevalent endocrine diseases. Metformin is used off-label in non-diabetic PCOS patients for years. Many studies have emphasized that metformin has positive effects on normal menstrual cycle and ovulation in addition to its metabolic and reproductive benefits such as weight loss, reducing insulin …
Sep 13, 2024 · Considering the evidence, we aimed to perform a systematic review and network meta-analysis of RCTs to evaluate the efficacy of exercise training on BMI, sex hormone concentrations (luteinizing hormone [LH] and follicle-stimulating hormone [FSH]), and regular menstruation in women with PCOS.
The aim of the present systematic review and meta-analysis has been to evaluate through anthropometric, metabolic, and hormonal parameters the impact of KD in overweight or obese patients with PCOS.
Dec 9, 2024 · BACKGROUND AND PURPOSE: Scragg et al. (Annals of Internal Medicine, 2024) quantified the effect of weight loss interventions on clinical features of polycystic ovary syndrome (PCOS) METHODS: Systematic review and meta-analysis Inclusion criteria Randomized controlled trials Studies that compared interventions aimed at reducing weight against usual …
Jan 1, 2020 · The underlying pathophysiology of PCOS, based on our current understanding, can be mainly attributed to elevated LH (Luteinizing Hormone)/FSH (Follicle Stimulating Hormone) ratio and/or insulin [2].
Jul 7, 2025 · A multivariate analysis was performed to determine the independent effects of PCOS and obesity for reproductive and metabolic parameters. Women with PCOS presented significantly higher AMH levels, LH: FSH ratio, and lower FF progesterone levels, confirming these as PCOS-specific signatures regardless of BMI.
May 19, 2020 · One meta-analysis of eight studies in PCOS adult women recommended a hypocaloric diet for the reduction of BMI, treatment of PCOS with insulin resistance, prevention of high LDL-C, increasing the levels of FSH and SHBG, and decreasing the level of TG level [58].
Aug 1, 2021 · Meta-analysis comparing the levels of total testosterone, estrogen, fasting insulin, LH, FSH, and LH/FSH before and 3 months after bariatric surgery. LH = luteinizing hormone; FSH = follicle-stimulating hormone.
Jul 1, 2025 · The pathophysiology of this syndrome involves disruptions in hormonal signaling, particularly changes in levels of luteinizing hormone (LH), and follicle-stimulating hormone (FSH) which can lead to anovulation and infertility. Additionally, insulin resistance and dysfunctional adipose tissue are other complicating factors of this condition.
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